With most print jobs, you should have specifications to adhere to. These specs work for preparing advertisements, brochures, business cards, and other printed mediums.
- CYMK vs RGB
A lot of the colors you create in RGB mode are not achievable using standard four-color process printing. It is always best to create your document from the start in CMYK color mode to ensure that you have a better idea of how your colors are going to print.
Some exceptions are tradeshow signs or large format prints, but the best way to know for sure is to check with the printer.
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